What are the system requirements for Twixl Publisher ?
Twixl Publisher Plug-in for InDesign CS5/CS5.5 requirements
see the Adobe site for details.
IMPORTANT NOTE: Although the plug-in can be used on both Windows and Mac OS X, the Twixl Publisher Builder app is Mac OS X only.
Twixl Publisher Builder requirements
Mac OS X 10.6.8 or 10.7.x and Xcode 4.x. Xcode is a free download from the Mac App Store.